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Responsible Research with 4-AcO-MET

Always practice responsible research. You should read and educate yourself before undertaking research with any chemical. The Psychonaut Wiki has some very helpful resources and information on 4-AcO-MET. Never conduct research with a chemical without learning about it first.

WARNING This product is not for human or veterinary use.

What is 4-AcO-MET?

4-Acetoxy-N-ethyl-N-methyltryptamine (also known as 4-AcO-MET, Metacetin, and Azomet) is a lesser-known novel psychedelic substance of tryptamine class. Members of this group produce psilocybin-like psychedelic effects when administered. It is structurally related to psychedelic tryptamines like 4-AcO-DMT, 4-AcO-DET, and 4-AcO-MiPT.

4-AcO-MET is closely related in structure to 4-HO-MET, for which it is theorized to act as a prodrug.

4-AcO-MET is occasionally found in pressed pill which are sold on the streets in northern Switzerland under the name “Acomet” or “Azomet”.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-AcO-MET, and it has little history of human usage. It is sold as a research chemical online. It is highly advised to use harm reduction practices if using this substance.

Chemical Properties

4-AcO-MET or 4-Acetoxy-N-methyl-N-ethyltryptamine is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-AcO-MET is substituted at R4 of its indole heterocycle with an acetoxy (AcO) functional group CH3COO−. It also contains a methyl group and an ethyl chain bound to the terminal amine RN of its tryptamine backbone (MET). 4-AcO-MET is an acetate ester analog of 4-HO-MET and the N-substituted ethyl homolog of 4-AcO-DMT.

Pharmacological effects

4-AcO-MET’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

It is also hypothesized that this compound is quickly hydrolyzed into the free phenolic 4-HO-MET, although human studies concerning the metabolic fate of this drug are lacking. This would explain a somewhat similar experience in their subjective effects. This is similar to how 4-AcO-DMT is thought to be deacetylated to 4-HO-DMT during first pass metabolism and subsequent passes through the liver.

Some of the most commonly reported effects are:

  • Sedation
  • Spontaneous physical sensations
  • Changes in felt bodily form
  • Analysis enhancement
  • Conceptual thinking
  • Delusion
  • Autonomous voice communication
  • Ego death
  • Emotion enhancement
  • Perception of interdependent opposites
  • Immersion enhancement
  • Increased music appreciation
  • Memory suppression
  • Novelty enhancement
  • Personal bias suppression
  • Thought acceleration
  • Thought connectivity
  • Thought loops
  • Time distortion
  • Unity and interconnectedness
  • Wakefulness
  • Enhancements
  • Distortions
  • Hallucinations
  • Colour enhancement
  • Pattern recognition enhancement
  • Visual acuity enhancement
  • Distortions
  • Drifting.
  • After images
  • Colour shifting
  • Environmental patterning
  • Scenery slicing
  • Symmetrical texture repetition
  • Tracers
  • Transformations
  • Internal hallucination

Potential Side Effects

  • Muscle contractions
  • Muscle relaxation
  • Excessive yawning
  • Watery eyes
  • Olfactory hallucination
  • Pupil dilation
  • Runny nose
  • Increased salivation
  • Teeth grinding
  • Nausea


4-AcO-MET is classified as illegal in:

  • Germany
  • Switzerland
  • United Kingdom

This list is not exhaustive, so do your own research into the legal status in your country before ordering!

Read More

All products are strictly for research purposes only and not for human consumption.

Store in a cool, dry place away from sunlight. Lysergamides and Tryptamines should be kept below 20'c where possible

Product Name: 4-AcO-MET hydrochloride powder

Other Name(s): 4-acetoxy-N-methyl-N-ethyltryptamine fumarate

CAS: 246-87-2

Chemical formula: C15H20N2O2

Molar mass: 260.337 g·mol−1

4-AcO-MET Fumarate

4.88 / 5 (8)
- +
NMR Measurment Report
NMR Measurement
Report Available

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Sample name: 4-AcO-MET 14-3-2021
Spectrometer: Bruker 500 MHz Solvent: D2O
Expected compound:
Identified compound:
4-AcO-MET fumarate
Estimated purity:

Click here for the full report.

SKU: 4ACOMET Category: Tags: , , ,
Read Reviews

8 reviews for 4-AcO-MET Fumarate

  1. W୩ (verified owner)

    good tryptamine, potent one

  2. W୩ (verified owner)


  3. W୩ (verified owner)

    Très bonne qualité. Plus visuels que le 4ho pour mon expérience.

  4. coiote80 (verified owner)

    Magic molecule, great night, good memories with 50mg dosage.

  5. Kilto (verified owner)

    It is one of my favorite tryptamine now, it dosen’t last too long but enough to have a very good trip, and not much after effetcs

  6. Vicente Niclós de Dulanto

    Espectacular medicina!!! Efectos iguales a la ayahuasca !!! Súper bien!! 30mg en dosis efecto comienza a las 20 minutos – 4 horas de viaje aprox. Recomendadisimo!!!

  7. johnymnemonick9

    Super thing, visuals are amazing, no anxiety.
    Definitely five starts.

  8. Alessandro Dolcetta (verified owner)

    Very good tryptamine, the best along with 4-Ho-Met, very visual and the music sound very very good

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