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What is 5-MeO-DMT?

Important: While 5-MeO-DMT and DMT are similar chemically, they have distinct effects and safety profiles from one another, so please do not substitute 5-MeO-DMT for DMT. They should be regarded as entirely different chemicals and treated as such.

5-MeO-DMT, sometimes referred to as “The God Molecule”, is a psychedelic in the tryptamine class. It’s found naturally in a wide variety of plant species, and at least one toad species – the Sonoran Desert toad (for more information on this topic, we highly recommend Hamilton Morris’s pamphlet “Bufo Alvarius: The Psychedelic Toad of the Sonoran Desert”).

It is closely related to DMT and 5-HO-DMT, and has traditionally been used as an entheogen in South America during tribal ceremonies.

5-MeO-DMT has sharply risen in popularity over the past few years as many anecdotal reports of its potential as a healing agent have come to light. Even mainstream media outlets such as Forbes have shone a light on the healing potential of this chemical.

While research into 5-MeO-DMT is limited, some studies have supported this anecdotal evidence. In a recent prelim study, 42 participants who took 5-MeO-DMT reported lower levels of depression and anxiety as well as higher levels of life satisfaction and mindfulness. The effects persisted for at least four weeks, when a follow-up assessment was completed.

Another study surveyed 362 people who had taken 5-MeO-DMT and found that 80% of respondents reported improvements in anxiety and depression.

What are the effects of 5-MeO-DMT?

5-Meo-DMT’s psychedelic effects are thought to primarily come from its efficacy as a partial agonist at the 5-HT2A receptor. In particular, it shows a high binding affinity for the 5-HT2A and 5-HT1A subtypes. However, not much is known about these interactions so our understanding of how they result in the psychedelic experience is limited at the current time.

5-MeO-DMT is also thought to inhibit reuptake of the neurotransmitters serotonin, noradrenaline, and dopamine, but little is known about the role these mechanisms play. As such, it is strongly advised to avoid combinations with SSRIs, SRIs, MAOIs, RIMAs or any other substance that acts a releasing agent or reuptake inhibitor of monoamine neurotransmitters (serotonin and dopamine for example).

Some of the most commonly reported effects are:

  • Stimulation
  • Dissociation
  • Suppression and release of anxiety
  • Feelings of physical and cognitive euphoria
  • A sense of unity and interconnectedness
  • Catharsis
  • Emotion enhancement
  • Ego death
  • Mindfulness
  • Rejuvenation
  • Autonomous voice communication
  • Thought connectivity
  • Time distortion
  • Unity and interconnectedness

Potential Side Effects

  • Dizziness
  • Respiratory depression
  • Increased heart rate
  • Muscle contractions
  • Muscle spasms
  • Muscle tremors
  • Motor control loss
  • Nausea
  • Pupil dilation
  • Spatial disorientation


5-MeO-DMT is classified as illegal in:

  • China
  • Australia
  • Sweden
  • Turkey
  • United States

This list is not exhaustive, so do your own research into the legal status in your country before ordering!

Responsible Research with 5-MeO-DMT

Always practice responsible research. You should read and educate yourself before undertaking research with any chemical. The Psychonaut Wiki has some very helpful resources and information on 5-MeO-DMT, so does The Third Wave and Set and Setting. We also have an Ultimate Guide to 5-MeO-DMT that’s well worth reading. Never conduct research with a chemical without learning about it first.

All products are strictly for research purposes only and not for human consumption.

Store in a cool, dry place away from sunlight. Lysergamides and Tryptamines should be kept below 20'c where possible

Product Name: 5-MeO-DMT freebase

Other Name(s): 5-methoxy-N,N-dimethyltryptamine

IUPAC Name: 3-[2-(dimethylamino)ethyl]-5-methoxyindole

CAS: 1019-45-0

Formula: C13H18N2O

Molar Mass: 218.3 g/mol

5-MeO-DMT Freebase

4.95 / 5 (20)
- +
NMR Measurment Report
NMR Measurement
Report Available

FREE UNTRACKED SHIPPING on orders of €50 or more!
FREE TRACKED SHIPPING on orders of €100 or more!

Sample name: ST-113 7-3-2021
Spectrometer: Bruker 500 MHz Solvent: CDCl3
Expected compound:
Identified compound:
5-MeO-DMT freebase
Estimated purity:

Click here for the full report.

SKU: 5MD Category: Tags: , , , ,
Read Reviews

20 reviews for 5-MeO-DMT Freebase

  1. Miguel91 (verified owner)

    La livraison était rapide comme d’habitude. Rien à redire sur le service.
    Le produit est de très bonne qualité. Ne pas abuser et tester avec de petites avant car il n’est pas à prendre à la légère.
    Globalement, entièrement satisfait :))

  2. JanHaklik (verified owner)

    So beautiful molecule! Be carefull, it is hugest mind changer. 😀 sitter is an obligation.

  3. R3RED7

    The most powerful thing I’ve ever seen.
    The same as HCL but more difficult to use.
    It’s stay in the body as a multiplier for weeks and then a small dose of lsd (150mcg) is enough and you can have full experience again like with 5-meo.

  4. aski12345a

    Me gustaría volver a probar, pero cuídense con la dosificación, es muy fuerte

  5. aski12345a

    profucto muy interesante y a la espera de volver a tenerlo

  6. Iván Fores Palau

    Interesante producto

  7. bonanus

    Incredible service and product quality! Packaging, customer service, and delivery are all exceptional. The product is pure. I second the notion of preparing for dosing. I ordered a microgram scale at the same time and it is essential. The dose is not something you want to eyeball!

  8. Ebij

    Shipped with care and kindness, with nice flyer and goodies
    This substance is out of earth is outstanding when carefully dosed.

  9. barry (verified owner)

    Phenomenal as always honestly with CC you really cant go wrong ive never been disapointed

  10. Loiso

    An interesting but very specific substance. When ordering small quantities, you should be concerned about correct dosing beforehand, as its ‘strength’ is higher than expected from other tryptamines. The free base evaporates very easily, but also overheats easily. Susceptible individuals may experience nausea or a stomach ache and it is best to take care of this immediately so as not to ruin the research).
    The delivery is brilliant!

  11. ShiningStar (verified owner)

    Real deal. I ordered rc’s from this website of over 100€ and they always delivered. Could’nt recommend them more. + they give you cute stickers

  12. Yabumethod

    Fast delivery, good quality and great customer support.

    Entrega rápida, buena calidad y excelente atención al cliente.

  13. ZalupaBolshayaUMenya

    OMG It’s so powerful!!!
    And quality is amazing

  14. Zes

    Vandy vape vap emesh ss316 works great 75w 175 Celsia.. Start small be extra careful with seting safe nature far from people u may atract with unusual noise please check video to know what to expect. Much love

  15. Shulg

    What a chem! Potent as fuck!
    Careful with dosage.

  16. Jimmy420

    tiene buena pinta

  17. geloloco (verified owner)

    important for cc managers.
    the dpd delivery company in germany may be a good option
    But in Spain, the person responsible for deliveries is SEUR, which is terrible and usually has bad reviews and mistreatment with customers, there are other companies like MRW that would be more competent, I say this to help I love this page.

    • Jack

      Thanks for the suggestion! We will look into other options for Spain if DPD is very unreliable.

      The other options we can use are GLS or PostNL (which usually uses the national postal service of the destination country). Let us know if you think they would be better!

  18. geloloco (verified owner)

    I have received it perfectly
    I have not tried it yet
    very professional and close, I have also received a letter about the substance with a beautiful art.
    it looks good

  19. aliendope (verified owner)

    Take care and let you go…. feel the univers vibrations

  20. Nilhuse721 (verified owner)

    It is good old 5 Meo DMT, looks like brown sugar, 250mg is enough for at least a 100 people ! So take care and have a safe research 😉

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