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Phenethylamines (or more specifically substituted phenethylamines) are a large group of organic compounds based upon the phenethylamine structure. They encompass an incredibly wide variety of psychoactive substances as well as hormones found naturally in the body. The pharmacological effects of substituted phenethylamines also vary substantially, so one should not expect a similar subjective experience just because two compounds happen to fall within this same chemical class.
Some examples of different classes that share the phenethylamine base structure are central nervous stimulants (for example, amphetamines such as 3-FEA), hallucinogens (such as 2C-B-FLY and methallylescaline), entactogens (like 5-MAPB), appetite suppressants and antidepressants. Phenethylamines also include numerous endogenous hormones, such as dopamine (the “reward system” hormone), norepinephrine (also known as adrenaline – the “stress” hormone), tyramine and others.
As you can see, the class “substituted phenethylamines” includes a whole host of different chemicals and hormones, some producing substantially different pharmacological effects from one another. The reason for this is because, while they share the same base structure, phenethylamines do not have a single common biological target or method of action; as opposed to – for example – the lysergamide chemical class, of which all derivatives target the 5-HT receptors.
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