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Responsible Research with 3-MeO-PCE
Always practice responsible research. You should read and educate yourself before undertaking research with any chemical. The Psychonaut Wiki has some very helpful resources and information on 3-MeO-PCE. Never conduct research with a chemical without learning about it first.
WARNING This product is not for human or veterinary use.
What is 3-MeO-PCE?
3-Methoxyeticyclidine (also known as Methoxieticyclidine and 3-MeO-PCE) is a novel dissociative substance of the arylcyclohexylamine class that produces dissociative and hallucinogenic effects when administered. It is a structural analog of PCE.
3-MeO-PCE began to gain popularity in 2010  and is sold on the online grey area research chemical market as a legal alternative to PCP or ketamine.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 3-MeO-PCE, and it has a very brief history of human usage. It is strongly recommended that one use harm reduction practices if using this substance.
3-MeO-PCE, or N-Ethyl-1-(3-methoxyphenyl)cyclohexan-1-amine, is classed as an arylcyclohexylamine drug. Ayrlcyclohexylamine drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. 3-MeO-PCE contains a phenyl ring with a methoxy (CH3-O-) substituent at R3 bonded to a cyclohexane ring. Bound to the same carbon (R1) of the cyclohexanone ring is an amino ethyl chain -NCH2CH3. 3-MeO-PCE, like MXE, contains an amino ethyl chain rather than the amino methyl chain found in DCK and ketamine. 3-MeO-PCE is analogous to MXE, but lacks an R2 substituted ketone. It is also homologous to 3-MeO-PCP but lacks the additional carbons to complete a piperidine ring.
3-MeO-PCE acts principally as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.”
3-MeO-PCE has Ki values of 61 nM for the NMDA receptor, 743 nM for the dopamine transporter, 2097 nM for the histamine H2 receptor, 964 nM for the Alpha-2A adrenergic receptor, 115 nM for the serotonin transporter, 4519 nM for the σ1 receptor and 525 nM for the σ2 receptor. 
Some of the most commonly reported effects are:
- Perception of bodily lightness
- Spontaneous physical sensations
- Physical euphoria
- Bodily control enhancement
- Tactile enhancement & Tactile suppression
- Anxiety suppression
- Cognitive euphoria
- Conceptual thinking
- Creativity enhancement
- Déjà vu
- Memory suppression
- Ego death
- Immersion enhancement
- Increased music appreciation
- Analysis suppression
- Acuity enhancement
- Colour enhancement
- Tactile disconnection
- Visual disconnection
- Consciousness disconnection
Potential Side Effects
- Increased blood pressure
- Increased heart rate
- Respiratory depression
- Physical autonomy
- Olfactory hallucinations
- Optical sliding
- Spatial disorientation
- Increased perspiration
- Difficulty urinating
- Double vision
- Frame rate suppression
- Pattern recognition suppression
- Visual acuity suppression
- Delusions of sobriety
- Compulsive redosing
3-MeO-PCE is classified as illegal in:
- United Kingdom
This list is not exhaustive, so do your own research into the legal status in your country before ordering!
How to Buy 3-MeO-PCE
You can buy 3-MeO-PCE and other dissociatives like 3-HO-PCE, 3-MeO-PCP, and DCK here at Chemical-Collective. All of our chemicals are third party lab tested.
All of our chemicals are strictly for research and analytical purposes only and not for human consumption.
If you wish to see NMR results for 3-MeO-PCE or any other chemical, please email us at email@example.com.
All products are strictly for research purposes only and not for human consumption.
Store in a cool, dry place away from sunlight. Lysergamides and Tryptamines should be kept below 20'c where possible
Product Name: 3-MeO-PCE hydrochloride
Other Name(s): 3-methoxyeticyclidine hydrochloride
IUPAC Name: N-ethyl-1-(3-methoxyphenyl)cyclohexan-1-amine hydrochloride
Molar Mass: 269.8 g/mol
Oeleiop (verified owner) –
Clear-headed soft functional energy
Vakaloura (verified owner) –
Nada que objetar en lo referente a la calidad de esta sustancia, simplemente decir que no es para mí. Importante, imprescindible, báscula para tratar con ella.
Napman (verified owner) –
Great substance, low price, and top purity from the chemical collective! Love you guys!
anormllife22 (verified owner) –
stellar purity stellar effects
hmmmmm OMG, after 3 meO PCP gone, this one is my new FAVORITE !! long live PCE !!
vom.grass (verified owner) –
Very interesting substance. Veeeery very long come-up, but when my rats found out how to work with 3-meo-pce, they told me it was mistake to redose because it’s weak. It isn’t, just be patient. They were really happy and satisfied, and they also told me to give you 5 stars.
eth-kh (verified owner) –
Compared to the cousin compound with a complete ring at Rn substitution, this one provides more relevant research outcomes. Simulations of in vivo pharmacodynamics predict more balanced profile. Repeated experiments provide incremental data points. Corrosion of reactor chambers happens too, but to a lesser degree.
It’s not as extreme as some other reports suggest. Couldn’t see that “manic/euphoric stimulation”.
It’s not sedating though. Kinda trippy.