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Responsible Research with 3-HO-PCP

Always practice responsible research. You should read and educate yourself before undertaking research with any chemical. The Psychonaut Wiki has some very helpful resources and information on 3-HO-PCP.

WARNING This product is not for human or veterinary use.

What is 3-HO-PCP?

3-Hydroxyphencyclidine (commonly known as 3-HO-PCP) is a novel dissociative substance of the arylcyclohexylamine class that produces potent dissociative, hallucinogenic and euphoric effects when administered. In addition to its primary activity as a NMDA receptor antagonist, it has been found to have appreciable affinity for the μ-opioid receptor.

3-HO-PCP was first synthesized in 1978 to investigate the structure-activity relationship of phencyclidine (PCP) derivatives. It was further explored alongside PCP in the 1980s, where it was discovered to possess μ-opioid agonist activity in animal models.

Like other substances of its class, particularly methoxetamine (MXE), phencyclidine (PCP), and 3-MeO-PCE, it is known to primarily induce a state referred to as “dissociative anesthesia”, albeit the extent to which this occurs has been reported to be highly dose-dependent and variable in its effects. It is unknown whether the studied opioid properties in animal models applies to humans, with some early reports suggesting that it does not.

Today, 3-HO-PCP is almost exclusively distributed as a gray area research chemical by online vendors. Extremely little is known about its pharmacology, metabolism and toxicity in humans. Due to its sensitive dose-response, potential habit-forming properties, as well as unknown toxicity profile, it is strongly recommended that one use proper harm reduction practices if choosing to use this substance.

Chemical Properties

3-HO-PCP, or 3-hydroxyphencyclidine, is a synthetic dissociative of the arylcyclohexylamine class. The structure of 3-HO-PCP consists of cyclohexane, a six-membered saturated ring, bonded to two additional rings at R1. One of these rings is a piperidine ring, a nitrogenous six member ring, bonded at its nitrogen group. The other ring is an aromatic phenyl ring, substituted at R3 with a hydroxy group.

3-HO-PCP is a structural analog of PCP and a homolog 3-MeO-PCP.

Pharmacological effects

Like other arylcyclohexylamine dissociatives, 3-HO-PCP acts principally as an NMDA receptor antagonist. The NMDA (N-Methyl-D-Aspartate) receptor, a specific subtype of the glutamate receptor, modulates the transmission of electrical signals between neurons in the brain and spinal cord; for the signals to pass, the receptor must be open. Dissociatives inhibit the normal functioning NMDA receptors by binding to and blocking them. This disruption of neural network activity causes network disintegration, some research suggests, by hyperconnectivity throughout the brain. This causes an increase in noise (random, nonsensical and erroneous data) on the cerebral network and thus produces loss of normal cognitive and affective processing, psychomotor functioning, anesthesia. This is often observed in those showing psychosis or induced with high-dose IV THC or Ketamine in healthy participants.

Unlike many other dissociatives, 3-HO-PCP has also been found to have appreciable affinity as a μ-opioid receptor agonist in animal models. However, the extent to which this applies to humans remains unknown.

Some of the most commonly reported effects are:

  • Stimulation
  • Spontaneous bodily sensations
  • Anxiety suppression
  • Physical & cognitive euphoria
  • Tactile enhancement 

Potential Side Effects

  • Sedation
  • Conceptual thinking
  • Déjà vu
  • Orgasm suppression
  • Ego death


3-HO-PCP is classified as illegal in:

  • United Kingdom
  • Switzerland
  • Sweden
  • Turkey

This list is not exhaustive, so do your own research into the legal status in your country before ordering!

How to Buy 3-HO-PCP

You can buy 3-HO-PCP and other dissociatives like 3-HO-PCE, 3-MeO-PCP, and DCK here at Chemical-Collective. All of our chemicals are third party lab tested.

All of our chemicals are strictly for research and analytical purposes only and not for human consumption.

If you wish to see NMR results for 3-HO-PCP or any other chemical, please email us at requests@chemical-collective.com.

Read More

All products are strictly for research purposes only and not for human consumption.

Store in a cool, dry place away from sunlight. Lysergamides and Tryptamines should be kept below 20'c where possible

Product Name: 3-HO-PCP hydrochloride

Other Name(s): 3-hydroxyphencyclidine hydrochloride

IUPAC Name: 1-[1-(3-hydroxyphenyl)cyclohexyl]-piperidine hydrochloride

CAS: 79787-43-2

Molar Mass: 295.9 g/mol


4.85 / 5 (13)
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NMR Measurment Report
NMR Measurement
Report Available

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Sample name: ST-211 26-7-2022
Spectrometer: Bruker 600 MHz Solvent: D2O
Expected compound:
Identified compound:
Estimated purity:
-HO-PCP NMR Report Screenshot

Click here for the full report.

SKU: 3HPP Category: Tags: ,
Read Reviews

13 reviews for 3-HO-PCP HCL

  1. Jfraktal (verified owner)

    Good quality!
    Be sure tu use precision scale ’cause the dosage is very low.
    A strong euphoria, energic and trippy experience with this molecule.
    But if you take too much it can be maniac, overstimulated and bad mood going on, take care with research!

  2. LampkaNocna (verified owner)

    Fast shipping , great product , although I don’t like the effects of this product in research

  3. Oeleiop (verified owner)

    Feels very clean, quite sedating

  4. willy (verified owner)

    super produit

  5. willy (verified owner)

    produit de très bonne qualité

  6. nDee

    Just a small sniff of truth..is that for children? My cat was yawning 😉

  7. MikePL (verified owner)

    The purity of the material is stunning. HI TEC.

  8. Forestakias

    Warm, clearheaded, no confusion or paranoia. This and DCK are thw GOAT 👽👽👽

  9. Dr Dylan

    In my opinion one of the best dissos i ever had around 7mg insuflated ! A blast ! Lasted pretty long, like sweet waves, pretty strong for so few.. i recommend strongly 😉

  10. darke707 (verified owner)


  11. Jzack

    Excellent. What I asked for. Lasted for many sessions of research. Overall good.

  12. ChickenCobra (verified owner)

    High quality product. Well Tested!

  13. Sjofn

    that goood goooooooooooooood

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