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Ratings from 18 reviews

Produced by Lizard Labs

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Responsible Research with O-PCE

Always practice responsible research. You should read and educate yourself before undertaking research with any chemical. The Psychonaut Wiki has some very helpful resources and information on O-PCE. Never conduct research with a chemical without learning about it first.

WARNING This product is not for human or veterinary use.

What is O-PCE?

2′-Oxo-PCE (also known as as Eticyclidone, and O-PCE) is a lesser-known novel dissociative substance of the arylcyclohexylamine class that produces dissociative, anesthetic, stimulating and hallucinogenic effects when administered. It is structurally related to arylcyclohexylamines like MXE, 3-MeO-PCE, and deschloroketamine and is speculated to produce its effects through its activity as an NMDA receptor antagonist.

The structural similarities O-PCE shares with DCK and ketamine which has been speculated to have antibacterial properties,[1][2] has raised some concern as to whether it also shares these properties as well. However, due to the lack of scientific research on the subject, whether this is true currently remains entirely unknown. It is advised that users of this substance should keep in mind that the possibility of prolonged use may pose a serious threat to one’s health and immune system if this does prove to be the case.

O-PCE is an example of a contemporary designer drug specifically chosen to mimic and/or replace the functional and structural features of its predecessors. It has recently become commonly available through online research chemical vendors[3] where it is being marketed and sold as a designer drug replacement for MXE and other dissociatives for recreational purposes. Unlike many other research chemical dissociatives, there is almost a total absence of scientific literature on O-PCE, particularly with regards to its toxicity, addiction and abuse potential in humans.

Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with extreme caution. Users should also avoid frequent redosing as it is reported to be relatively easy to overdose due to its potency and stimulating nature. It is strongly recommended that one use harm reduction practices if choosing to use this substance.

Chemical Properties

O-PCE, or 2′-Oxo-PCE, belongs to the arylcyclohexylamine chemical class. Arylcyclohexylamine drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. Deschloroketamine contains a phenyl ring bonded to a cyclohexane ring substituted with an oxo group (cyclohexanone) at R1. Bound to the adjacent alpha carbon (R2) of the cyclohexanone ring is an amino ethyl chain -NCH2CH3. 2′-Oxo-PCE, like MXE contains an amino ethyl chain rather than the amino methyl chain found in DCK and ketamine. 2′-Oxo-PCE is homologous to DCK, differing only in the length of their carbon chain.

Pharmacological effects

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as ketamine, PCE and methoxetamine (3-MeO-2′-Oxo-PCE). While no scientific studies have been conducted to verify this, structure-activity relationship analysis suggests that 2′-Oxo-PCE likely exhibits its observed effects principally as an NMDA receptor antagonist, although other neurotransmitter systems may be involved.[citation needed]

NMDA receptors (a subtype of receptors for glutamate, which are the principle excitatory neurotransmitters in the nervous system) allow for electrical signals to pass between nerve cells in the brain and spinal column; for the signals to pass, the receptor must be open. NMDA receptor antagonists have been shown to disrupt this signaling by blocking these receptors. This disconnection of information flow in the nervous system leads to loss of sensation (anesthesia), difficulty moving (motor discoordination), and eventually this substance’s equivalent of the “K-hole.”


O-PCE is classified as illegal in:

  • Switzerland
  • United Kingdom

This list is not exhaustive, so do your own research into the legal status in your country before ordering!

Read More

All products are strictly for research purposes only and not for human consumption.

Store in a cool, dry place away from sunlight. Lysergamides and Tryptamines should be kept below 20'c where possible

Product Name: O-PCE hydrochloride

Other Name(s): 2′-oxo-PCE, eticyclidone hydrochloride

IUPAC Name: 2-(ethylamino)-2-phenyl-cyclohexanone hydrochloride

CAS: 4551-92-2

Molar Mass: 253.8 g/mol

NMR Measurment Report
NMR Measurement
Report Available
Sample name: AC-07 1-5-2023
Spectrometer: Bruker 600 MHz Solvent: CDCl3
Expected compound:
Identified compound:
Estimated purity:
O-PCE HCL NMR page 1

Click here for the full report.

SKU: O-PCE-HCL Categories: , , Tags: ,

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Read Reviews

18 reviews for O-PCE HCL

  1. michalkutlak (verified owner)

    Best disso for k hole.

  2. takozaki (verified owner)

    Great product, very neutral feel, quite versatile. Stealth was great too.

  3. Boaz08 (verified owner)

    amazing stuff. very potent and basically great via all routes.

  4. Oeleiop (verified owner)

    It is just perfect !

  5. Space Cooker (verified owner)

    Our initial test showed a strong dissociative paired with a warm stimulation, comedown has a glowing positive light.
    We also observed some strong anti-depressive effects lasting up to 2 weeks on our guinea pigs after consumption.
    One should’ve be careful with dosage as this product is very potent.
    Overall it’s a top research subject Thx CC !

  6. Shulg

    This chem is fucking potent!
    Rough one, careful with dosages with your researchs.
    Easily lead to confusion, pretty stimulant character, too potent for my research.
    More way to handle it is to research it mixed in E-liquid on your E-cig.

  7. Herbalchemishop (verified owner)

    Very interesting researching this substance in relation to its reaction to temperature aiming up, does anyone wanna share vaporization point (not inhaling! nut wearing gasmask!) of this substance? .)

  8. Napman (verified owner)

    Top product, excellent purity. VERY hole-friendly. Best vendor around by far with top-notch customer service. You earned a loyal customer.Thank you, guys!

  9. anormllife22 (verified owner)

    freaking amazing this is my new number 2 fav disso ( #1 being dmxe)
    #2 was ket

  10. bananarang (verified owner)

    Looking to explore the cosmos? Well, this chemical will guide you. Simply amazing. 🙂

  11. barry (verified owner)

    Very clean and highly recommended

  12. InVivoFrance

    AWESOME product ^^

  13. Lyon (verified owner)

    Amazing disso a bit more stimulating than the other ones and love the mania only downside is it can get quite intens real fast

  14. Wussi (verified owner)

    Ich habe es wie alle Substanzen im DIZ abgegeben.
    Ich sollte demnächst den Analysebericht bekommen. Bin schon gespannt darauf.
    Wieso versendet dieser Vendor nicht in die Niederlande, wenn s dir doch noch viele legale RCs gibt? Das wundert mich schon etwas.

    Ich gebe erst einmal drei Sterne, korrigieren ist ja immer möglich.

    • Jack

      Hi there.
      It’s great to hear you’re getting this tested. It’ll be interesting to compare with the third party HNMR results we recieved.
      We’re actually based in the Netherlands and do ship domestically. If you found some Dutch shipping restrictions on one of our products or something please let us know as we’ll need to correct it!
      Thank you for being a responsible member of the community and running your own tests.
      All the best,

  15. Unknown Flowing Subject (verified owner)

    My absolute Fav!

  16. Dave

    Sehr potentes Disso. Echt geil, vorallem auch die leicht trippige Seite mochte ich sehr. Aber Vorsicht mit der Dosierung, da hoch potent.. Besser vorher im internet schlau machen über die genauen Dosierungen! Sehr schade dass es bald vom NPSG verboten wird..

  17. juggalotus0075 (verified owner)

    I don’t have words, simply angellic.

  18. Sjofn

    it’s literally TOO good, be careful. i mean this in the best way possible.

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