1cP-LSD – The Ultimate Guide

Disclaimer: The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of Chemical Collective or any associated parties.

UPDATE: 1cP-LSD was unfortunately banned in Germany in 2021. Please read our article here to learn more. The latest legal LSD analogue is 1D-LSD (although it is likely to be banned in Summer 2024).

What is 1cP-LSD?

1cP-LSD (1-Cyclopropionyl-d-lysergic acid diethylamide) a novel semi-synthetic psychedelic substance of the lysergamide class. An analogue of LSD, it first appeared on the online research chemical market in July 2019. Since then it has grown greatly in popularity in the research community.

Researchers have frequently reported it to be around 20-30% more potent than its close cousin 1P-LSD. It’s therefore advised to be cautious when running experiments with this compound. If unsure, always start small before working your way up to larger experiments.

Pharmacology of 1cP-LSD

1cP-LSD is an analogue and close relative of LSD and 1P-LSD, and it’s reported to induce almost identical pharmacological effects to its predecessors. These effects are thought to be caused by interactions with the serotonin 5-HT2A receptors distributed throughout the brain.

1cP-LSD also likely interacts with a wide range of monoamine receptors, such as those for dopamine and norepinephrine. However, this is speculation based on observations of how LSD interacts with the brain as there is little to no data yet on the exact mechanisms specific to 1cP-LSD. It’s assumed the mechanisms are almost identical to 1P-LSD and LSD. This is due to the similarities in molecular structure and reported pharmacological effects.

Subjective Effects of 1cP-LSD - Physical, Auditory, Visual, and Cognitive Effects

Please note: Self-reported experiences are entirely subjective and should therefore be approached with a healthy dose of skepticism. It’s also worth noting that these effects will not necessarily occur in a consistent or reliable way and each experience will differ to a greater or lesser extent.

Please note this list is not exhaustive. Always do your own research before doing experiments with any compound. Negative effects are much more common at higher doses. Remember to start small and work your way up. Always practice good set and setting when conducting research.

Some 1cP-LSD Trip Reports from Reddit and Erowid

There are many very interesting and detailed trip reports available online from various sources including but not restricted to Reddit and Erowid. Learning about the pharmacological effects of 1cP-LSD should be of paramount interest to any researcher interested in studying the compound, so we highly recommend you take the time to read as much as possible as it may influence the direction of your work. Here we’ll look at four experiences; three from Reddit and one from Erowid.

Trip Reports - Further Reading

If you’re interested in checking out some other trip reports, Nervewing does a great job of compiling trip reports with many substances, including 1cP-LSD, into her blog. You can read it here.

The guys over at Set & Setting also provide great blogs and articles about the structured, responsible, and safe use of psychedelics.

Erowid has been around for years and the website feels pretty outdated and clunky by today’s standards. Despite this, it offers the largest repository of trip reports on the internet. A very valuable resource.

Microdosing 1cP-LSD

1cP-LSD has been gaining popularity in the microdosing community over the past few years. Microdosing is the practice of consuming very low, sub-hallucinogenic doses of a psychedelic substance to achieve an enhanced cognitive state. If you would like to learn more about microdosing this is a great resource to dive into.

Where can I buy 1cP-LSD?

If you’re interested in buying 1cP-LSD for use in your lab and are wondering how to buy it quickly and safely, we’ve put together this handy guide on How to Buy Research Chemicals, including 1cP-LSD, that will walk you through the process.

You can also buy 1cP-LSD (along with many other compounds) in our shop. As always, please be careful and do your own research before making any decision to purchase research chemicals online. Be sure to request NMR results if you’re unsure of the quality of a product. Chemical-collective has all of their products third-party tested and the NMR test results are available upon request. Please email us at request@chemical-collective.com for more information.

Dr. Rick Dagless MD | Guest Blogger at Chemical Collective