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DMXE – The Ultimate Guide

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Table of Contents
How does DMXE work?
Potential effects


DMXE, the abbreviation of Deoxymethocetamine, is a relatively new chemical  from the arylcyclohexylamine family. It is an analogue of methoxetamine (a well-known dissociative, commonly known as MXE) and was first synthesised in October 2020. Despite being so young, DMXE’s popularity has grown exponentially in a very short period of time, largely due to its reported similarities to MXE. Nervewing, a Poet, psychonaut, and much-loved community member, described DMXE as both“delightful and exciting”. 

Reports of DMXE vary from feelings of euphoria, to “rushes”, to intense stimulation. Although it was originally intended to be very similar to MXE, DMXE is a unique compound in its own right, as many research reports comment that there are substantial differences between the two.

How does DMXE work?

DMXE Hydrochloride powder.

DMXE mainly functions as an NMDA receptor antagonist. NMDA receptors are located in the excitatory synapses and participate in neurotransmissions in the central nervous system. They also play a crucial role in regulating neurological functions, such as memory formation and locomotion. 

Similar to that of ketamine and PCP, DMXE inhibits the actions of these receptors, inducing a feeling of “dissociative anaesthesia”. Like its close relative, MXE, DMXE has been often reported to cause  k-hole-like effects – its blocking of our NMDA receptors causes that familiar loss of feeling and difficulty moving. DMXE is often reported by researchers to have a longer trip duration and a higher potency than many common dissociatives.

Often described as similar to MXPr or MXiPr, but with more “psychedelia and body-high”, DMXE brings back strong feelings of nostalgia for our fellow MXE enthusiasts. 

Potential effects

A 40mg DMXE pellet.
  • Stimulation – most reports of DMXE mention an increase in sociability, unlike most other dissociatives. While DMXE doesn’t usually provide the same ‘rush’ of energy as amphetamine, it is generally considered to be one of the more stimulating dissociatives. The researcher’s experiences tend to be more active and functional, compared to reports of, for example, 2-FDCK. 
  • Euphoria – while you shouldn’t expect the same level of elation as with benzofurans such as 5-MAPB and 6-APB, DMXE is often reported to produce mild to moderate feelings of euphoria. This is likely due to its presumed method of action (based on the pharmacology of MXE) as a serotonin reuptake inhibitor (SRI), effectively exposing your 5HT receptors to more of your body’s serotonin. 
  • Dissociation – as with all arylcyclohexylamines, DMXE causes feelings of dissociation and disconnection from one’s mind and body, sometimes leading to a complete dissolution of the sense of self (AKA “ego death”), especially at higher doses. 
  • Hallucinations – some users (though not all) experience visual hallucinations on DMXE. These visuals generally consist of distortions of depth perception (objects that are very close can look very far and vice versa; or very small objects can look very large) and tracers/double-vision (where moving objects produce a blur/tracer behind them. 
  • Lightheadedness – reports of “dizziness” and “rushes” are often mentioned. This is most likely related to those feelings of euphoria and is mostly experienced in the “come-up” stage of your trip.
  • Loss of motor control – the physical inhibition associated with most dissociatives. Researchers often talk about feeling “droopy”, when your body’s physical sensories are delayed or muted and some reports discuss an acute lack of coordination. This effect will often become more prominent at higher doses.

Please note, this list is not exhaustive. Always do your own research before doing any experiments with any compound. 

Another reminder that self-reported experiences are entirely subjective and should therefore be approached with a healthy dose of skepticism. It’s also worth noting that these effects will not necessarily occur in a consistent or reliable way. Each experience differs to a greater or lesser extent. 

As an extremely new chemical, DMXE should be treated with caution and researched at the lowest doses first.

Written by Gigi McCath | Guest Blogger at Chemical Collective


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