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DMXE, the abbreviation of Deoxymethocetamine, is a relatively new chemical from the arylcyclohexylamine family. It is an analogue of methoxetamine (a well-known dissociative, commonly known as MXE) and was first synthesised in October 2020. Despite being so young, DMXE’s popularity has grown exponentially in a very short period of time, largely due to its reported similarities to MXE. Nervewing, a Poet, psychonaut, and much-loved community member, described DMXE as both“delightful and exciting”.
Reports of DMXE vary from feelings of euphoria, to “rushes”, to intense stimulation. Although it was originally intended to be very similar to MXE, DMXE is a unique compound in its own right, as many research reports comment that there are substantial differences between the two.
DMXE mainly functions as an NMDA receptor antagonist. NMDA receptors are located in the excitatory synapses and participate in neurotransmissions in the central nervous system. They also play a crucial role in regulating neurological functions, such as memory formation and locomotion.
Similar to that of ketamine and PCP, DMXE inhibits the actions of these receptors, inducing a feeling of “dissociative anaesthesia”. Like its close relative, MXE, DMXE has been often reported to cause k-hole-like effects – its blocking of our NMDA receptors causes that familiar loss of feeling and difficulty moving. DMXE is often reported by researchers to have a longer trip duration and a higher potency than many common dissociatives.
Often described as similar to MXPr or MXiPr, but with more “psychedelia and body-high”, DMXE brings back strong feelings of nostalgia for our fellow MXE enthusiasts.
Please note, this list is not exhaustive. Always do your own research before doing any experiments with any compound.
Another reminder that self-reported experiences are entirely subjective and should therefore be approached with a healthy dose of skepticism. It’s also worth noting that these effects will not necessarily occur in a consistent or reliable way. Each experience differs to a greater or lesser extent.
As an extremely new chemical, DMXE should be treated with caution and researched at the lowest doses first.
Written by Gigi McCath | Guest Blogger at Chemical Collective
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